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Endoplasmic Reticulum Stress Pathway ( ER Stress) Portal

The portal hosts detailed pathways of ER stress with more emphasis towards its role in heart

Freely accessible @ http://www.cidms.org/pathways/er_stress/ The endoplasmic reticulum (ER) is a multifunctional intracellular organelle supporting many processes required by virtually every mammalian cell, including cardiomyocytes. It performs diverse functions, including protein synthesis, translocation across the membrane, integration into the membrane, folding, posttranslational modification including N-linked glycosylation, and synthesis of phospholipids and steroids on the cytoplasmic side of the ER membrane, and regulation of Ca2+ homeostasis. Perturbation of ER-associated functions results in ER stress via the activation of complex cytoplasmic and nuclear signaling pathways, collectively termed the unfolded protein response (UPR) (also known as misfolded protein response), leading to upregulation of expression of ER resident chaperones, inhibition of protein synthesis and activation of protein degradation. The UPR has been associated with numerous human pathologies, and it may play an important role in the pathophysiology of the heart. ER stress responses, ER Ca2+ buffering, and protein and lipid turnover impact many cardiac functions, including energy metabolism, cardiogenesis, ischemic/reperfusion, cardiomyopathies, and heart failure. ER proteins and ER stress-associated pathways may play a role in the development of novel UPR-targeted therapies for cardiovascular diseases.

Type of project: academic

   

Involved Persons:

Project Leader: Pradeep Kumar Sreenivasaiah (Gwangju Institute of Science and Technology)
Other involved People: Jody Groenendyk, Do Han Kim, Luis B. Agellon, Marek Michalak

Funding:

Is the project funded?yes
Funding source:Canadian Institutes of Health Research; Korea Ministry of Education and Science and Technology (MEST)/National Research Foundn.

DIOC user:

Pradeep Kumar Sreenivasaiah (6 star_blue), Gwagju Institute of Science and Technology
Pradeep Kumar Sreenivasaiah's interests: clinical decision support, educational technology, bioinformatics, practice management, computer-based patient records, patients and computers/consumer health informatics, implementation/maintenance of IT, research methods

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